Nathaniel Ake would score five minutes later to seal the victory for Pep Guardiola’s side.
Despite dominating 78 ball possession, United could not salvage a point against Palace on their home turf.
United came into the game looking good at the start until the visitors struck, damaging the momentum of the home side.
Eric Ten Hag’s side could not build on their first win against Wolves, bowing to pressure from a better Spurs side.
The Red Devils eventually picked up the three points which took their season’s tally to 69 points.
“I feel betrayed by Man United. Manchester United tried to force me out,” Ronaldo revealed. “Not only the manager but also the other guys who are around the club.”