Scottish star, Scott McTominay, fires United ahead 36 minutes into the game courtesy of an assist from Jadon Sancho.
An Early goal by veteran striker Harry Kane ensured Spurs returned the favour for the 4-2 spanking they received at the Etihad a few weeks back.
This is Arsenal’s second defeat in the Premier League since the 3-2 to Manchester United at Old Trafford in September 2022.
Manchester United are into the fourth round of the Emirates FA following an impressive 3-1 victory over underperforming Everton on Friday night.
Manchester City, who knocked Chelsea out of the League Cup late last year, host Chelsea next Sunday in the FA Cup.
Notwithstanding City’s 75 per cent ball possession and 16 shots on target against Everton’s 25 per cent and two shots on target, the match ended 1-1.
With the points shared, Everton has now recorded their fourth consecutive draw while Liverpool awaits their first away victory of the campaign.
Southampton are now 7th on the EPL log with seven points in 5 games, while Chelsea are 8th on the log with seven points in 5 games.
In early kickoff, Liverpool will be slugging it out with newly promoted Fulham away from Anfield.
Richarlison becomes fourth summer signing for Spurs after Fraser Forster, Ivan Perisic and Yves Bissouma.