Aston Villa boosted their top-four hopes with a 2-0 win against bottom side West Ham to regain their confidence.
Tomas Soucek pulled one back for West Ham in the 49th minute when he guided home Malick Diouf’s pass from close range.
Wilshere succeeds Matt Bloomfield, who was sacked earlier this month after less than a year in charge at Kenilworth Road.
Crysencio Summerville scored his first goal in a West Ham shirt.
However, the title is still undecided, with Arsenal holding on to hope as they prepare to host Everton.
The Gunners broke through West Ham defence, netting four of their six goals within 15 minutes.
“The objective remains the same, which is to take the trophy home,” said man-of-the-match player Kudus.
With Thursday night’s defeat, Arsenal are now behind Liverpool with two points, having garnered 40 points in 19 games this season.
Players are expected to wear black armbands, with wreaths to be laid on the Old Trafford pitch and a minute’s silence observed before kick-off.
“It was frustrating when we missed the penalty. We were playing well, and we didn’t get the reward.”
