The World Health Organisation (WHO) says 35 countries in five regions of the world have now reported more than 1,010 probable cases of unexplained severe acute hepatitis  or liver inflammation in youngsters.

According to a new update on Wednesday from the WHO, the number of the cases reported is increasing since the outbreak was first detected on April 5.

The UN health agency is keeping an eye on the puzzling spread of hepatitis in previously healthy children, which has left dozens needing lifesaving liver transplants,  in addition to tackling COVID-19 and the monkeypox outbreak.

So far, 22 children have died and almost half of the probable cases have been reported in Europe where 21 countries have registered a total of 484 cases.

These include 272 cases in the United Kingdom – 27 per cent of the global total – followed by the Americas, whose regional total of 435 includes 334 cases in the US, representing a third of cases worldwide.

The next highest caseload is in the Western Pacific Region (70 cases), Southeast Asia (19) and the Eastern Mediterranean (two cases).

WHO said 17 countries had reported more than five probable cases but the actual number of cases may be underestimated in part owing to the limited enhanced surveillance systems in place.

According to the UN health agency’s latest assessment, the risk of this paediatric hepatitis outbreak spreading is “moderate.”

“Out of 100 probable cases with available clinical data, the most commonly reported symptoms were nausea or vomiting in 60 per cent of cases; jaundice, 53 per cent, general weakness, 52 per cent and abdominal pain account for 50 per cent. The average time between the onset of symptoms and hospitalisation was four days,” it said.

In laboratory tests, WHO disclosed that hepatitis A to E had not been present in the affected children. Other pathogens such as the coronavirus were detected in a number of cases, but the data is incomplete.

The UN health agency added that Adenoviruses – which cause a wide range of illnesses, such as colds, fever, sore throats and pneumonia – had been “the most frequently detected pathogen” in cases of paediatric hepatitis.

In Europe, adenovirus was detected by polymerase chain reaction tests (PCR) in 52 per cent of the child hepatitis cases (193/368) so far; in Japan, it was found in just nine per cent of cases (5/58).

Owing to limited adenovirus surveillance in most countries, it is quite possible that the true number of cases of child hepatitis is higher than currently known.

To promote better understanding of where the outbreak is happening, WHO has launched a global online survey, which will also help to compare current cases with data from the last five years.

(NAN)