The goal was Sesko’s 10th league goal of the campaign.
Harry Maguire and Lisandro Martinez both missed the game due to suspension.
United secured a first win at Anfield since January 17, 2016.
“It’s not about Andre. With all due respect, this is a fourth-division team. It’s not the goalkeeper. It’s more than that,” he said.
Maguire, Maddison, and five other players were dropped as the final team list was announced on Thursday ahead of a June 7 submission deadline.
Southgate had initially named a 33-man preliminary squad but had to drop seven before the June 7 deadline for countries to submit their final squads.
In his post announcing the news, the former Leicester City defender said he is “extremely disappointed” with the manager’s decision.
This victory becomes United’s thirteenth straight home win across all competitions this season.
Arsenal failed to extend their lead atop the Premier League table after they were held to a goalless draw by Newcastle United at the Emirates Stadium.
A video emerged on social media of Manchester United forward Ronaldo appearing to smash a fan’s phone as he left the field after Everton’s 1-0 English Premier League win in April.
