However, Marco Asensio could return from a hamstring injury sustained in the Supercopa de Espana success against FC Barcelona.
The Argentine won the trophy ahead of Robert Lewandoski, Jorginho, Karim Benzema, N’golo Kante, and Cristiano Ronaldo.
He was found guilty of complicity in the attempted blackmail of a former international teammate over a sex tape.
Manager Carlo Ancelotti said Hazard was suffering from gastroenteritis, while Bale picked up a knock last week on international duty with Wales.
Benzema faces up to five years in prison if convicted of blackmail linked to a sex tape featuring his former France teammate Mathieu Valbuena.
The two-year deal will see Benzema play for the Spanish giant till 2023.
