The confirmed and suspected cases were reported in the Pushit, Mangu 1 and Mangu 2 communities of Mangu Local Government Area.
Mr Abba-Kaza noted that the outbreak had spread to 36 wards and more than 138 communities.
The UN health agency calls for renewed commitments to build more sustainable national programmes.
Mr Boum said that a multisectoral rapid response team had been deployed.
A total of 376,573 people in affected districts have been vaccinated against cholera so far.
Sudan first announced the outbreak of cholera in August 2024.
The Africa Centres for Disease Control and Prevention says the continent recorded fewer disease outbreaks in January 2026 compared to the same period in 2025.
Mr Mallo said the call was imperative to ensure a rapid and effective response to cholera and other water-borne disease outbreaks.
Mr Boum II said Africa CDC is working with countries to prioritise cholera hotspots.
Mr Boum said that despite the progress, Africa continued to face serious health threats, particularly from cholera, diphtheria, and viral haemorrhagic fevers.
