United climbed to fifth on 17 points from 10 games, while Spurs, who failed to trouble United goalkeeper David De Gea, are eighth.
But Barcelona manager Ronald Koeman said his side was not inferior to Real Madrid on the night after losing 2-1 in the El Clasico match.
At the Stade Taieb Mhiri Stadium in Sfax, Diepreye Teibowei’s men were hit for four as their ambitions faded into thin air.
Zamalek’s qualification came after a 4-0 drubbing of Kenyan champions Tusker FC at the Borg El Arab Stadium in Alexandria, Egypt.
Ghanian midfielder Thomas Partey opened the scoring for Arsenal with a header 23 minutes into the game.
The Safety Babes on Friday beat Bayelsa Queens 27-19 to record a straight second win.
Messrs Sunday Dare and Musa Kida are said to have diverted money meant for the basketball team.
CAR beat Nigeria 1-0 in a World Cup qualifying match on Thursday in Lagos.
The Super Eagles announced that Iwobi who was injured will be replaced by Terem Moffi.
The visiting side Sheriff defeated Madrid, 13-time winner of the Champions League, 2-0.
