Kai Havertz scored the only goal of the game in the 37th minute.
Erling Haaland scored the only goal of the game.
Beto doubled the lead for Everton for the hosts in the 62nd minute, firing home a shot from close range that slipped in between Sanchez’s legs.
The Blues currently sit fourth on the table with 45 points.
The result also increased Arsenal’s unbeaten streak to 12 matches in all competitions after having not lost a game since the 1-0 defeat to Liverpool in August.
Reduced to ten men, the Blues were immediately put under pressure and United capitalised.
With crucial games approaching, Tottenham now head to face Burnley, Real Betis in the Europa League, and Sunderland.
Spurs maintained their unbeaten start under manager Thomas Frank following an opening 3-0 win over Burnley.
Champions Liverpool face Bournemouth in the season’s opening match as league organisers release the matchday schedules for the upcoming season.
Joel Piroe was at his best, scoring four goals in the first-half to end his long goal drought.
