The final set was one for the books.
Ash has now won three of the four Grand Slams and is 3-0 in grand slam finals.
Ngannou came in the underdog amid several issues surrounding his contract, fighting his former teammate, and his former coach.
The historic event was held in Lagos on Friday.
In the end, Usman got a unanimous decision victory; 48-47 on two of the judges scorecards and 49-46 on the other.
Canelo made history and is now the WBC, WBO super-middleweight, WBA Super and IBF titleholder.
Nigerian amateur wrestler Esther Omolayo Kolawole has won a bronze medal at the World Wrestling Championship in Belgrade, Serbia.
The fight had some animosity leading up to it as Jamel and Shakur had been longtime friends and trained together on many occasions.
Both fighters, however, were coming off losses to the champion Israel Adesanya heading into this fight.
An eleventh round KO saw Fury see off Wilder’s challenge and retaining his WBC title.