Liverpool bounced back from last week’s defeat to Arsenal to hand Manchester City their first defeat this season at Anfield.
The Reds came for a revenge having lost last season’s Premier League title to City.
Mane beat former Liverpool teammate Mo Salah, his compatriot, Chelsea goalie Edouard Mendy, to the award.
Salah’s contract renewal put to rest rumours linking him to possible transfer to Spanish side Real Madrid.
Salah then took to his Twitter page to share old photos of his celebratory moments with Mane.
The PFA Award is determined through votes cast by both present and former players.
The result meant the Pharaohs started off their qualification to next year’s Africa Cup of Nations (AFCON) on a victorious note.
With 15 goals and seven assists this season, De Bruyne won majority votes to beat Salah and other nominated players.
“If you compare me with any player in my position, not only in my team but in the world, you will find that I am the best,” he said
Things do not get any easier for Everton, with Chelsea up next at Goodison at the weekend.