The result for the Red Devils marks their second loss in four games of the new campaign.
Ipswich conceded an own goal in the 56th minute from Jacob Greaves.
Bruno Fernandes and Khadija Shaw have emerged as the winners of the men’s and women’s Professional Footballers’ Association Player of the Year Award.
The 41-year-old only had 25 touches during the match.
Although all players will have important roles in their respective teams’ campaigns in North America, attention is on a group of footballers expected to make the difference.
Gabriel Jesus and Noni Madueke scored Arsenal’s goals in the encounter, while Jean-Philippe Meteta netted Palace’s consolation.
United will face Brighton on the final day of the season.
The victory moves Michael Carrick’s side three points above Villa.
The Gunners restored their lead in the 66th minute through Jurrien Timber who headed home a well-placed corner kick by Declan Rice.
It is the first time the Red Devils have recorded four successive league victories in almost two years.
