The centre-back has been ruled out for up to three weeks with a hamstring injury.
Ecuador and Netherlands played a 1-1 draw Friday night to seal the fate of the host in the competition.
A goal each from Dutch sensation Cody Gakpo and Klaassen were enough to break the heart of the West African nation.
Liverpool thrashed Bournemouth 9-0 at Anfield to secure their first three points of the season.
Manchester United put up an impressive performance, thrashing Liverpool 4-0 on Tuesday.
A win for Manchester City will see Liverpool return to second position on the EPL log, with three points behind City.
The victory, Liverpool’s ninth in a row in all competitions, moved them on to 60 points from 26 matches, three behind Manchester City.
Van Dijk has extended his stay in Liverpool till 2025.
Van Dijk and Gomez have not played since October and November respectively after sustaining serious knee injuries.
Van Dijk was injured during a Premier League match with local rivals, Everton.
